Day: November 29, 2025

A woman stands at an open refrigerator holding a raw pork shoulder in a plastic bag, her other hand resting on the oven door handle.
Cooking

How Long to Cook Pork Shoulder at 350?

Short answer Cook pork shoulder at 350°F for about 35 to 45 minutes per pound, until the center reaches 145°F, then rest 3 minutes. For shreddable pork, expect longer cooking, usually until fork-tender rather than just safely cooked. How Long to Cook Pork Shoulder at 350: cook pork shoulder for about 35 to 40 minutes